Sarah Withey

Dr Sarah Withey

Dr Sarah Withey is a stem cell/ developmental biologist with a strong background in liver modelling for disease and drug development. She completed her PhD in 2016 in the lab of Prof Neil Hanley at the University of Manchester, UK, investigating the directed differentiation of human PSCs towards functioning hepatocytes, publishing highly recognised findings on the maturation status of the field (121 cites). In 2017, during her first postdoctoral position in a collaborative project with Professor Azim Surani and Dr Ramiro Alberio at University of Nottingham, UK, she used porcine embryos and hPSCs to model lineage segregation, pluripotency and germ cell development in the pre-gastrulation embryo, leading to a Nature publication and Nature Communications report under consideration. In January 2018 she became a postdoctoral research fellow at the University of Queensland Australian Institute for Bioengineering and Nanotechnology, in the lab of Professor Ernst Wolvetang. Here she is using human iPSCs differentiated towards hepatocytes to model patient-specific diseases and to determine the molecular mechanisms which underpin differences in the lineage propensity (with focus on endoderm) of iPSCs from a shared, isogenic background.

(Mon 10:30-12:30 Elston Room) Session 10: “Cutting Edge” Plenary
(11:10-11:20)  GRW009 — Improving Maturation of Human Pluripotent Stem Cell Derived Hepatocyte-Like Cells Through Small Molecule Targeting of Gene Regulatory Networks Identified in Adult Liver

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